Components of the Nuclear Pore Complex are Rising Stars in the Formation of a Subnuclear Platform of Chromatin Organization beyond Their Structural Role as a Nuclear Gate

The nuclear pore complex is a multiprotein comprising approximately 30 different proteins called nucleoporins (Nups). Recent studies in yeast, animals, and plants have shown that the Nups bind to chromatin interact with transcription factors, chromatin-remodeling histone-modifying enzymes, structural proteins, including CCCTC-binding factor cohesin. These findings suggest provide subnuclear platform for gene expression, organization, DNA repair.